Flavin‐Containing Monooxygenase 3 Genetic Variants and Possible Susceptibility to Coronary Heart Disease Among Han Chinese With Type 2 Diabetes

<b>Purpose:</b> To explore the flavin-containing monooxygenase 3 (FMO3) single-nucleotide polymorphisms (SNPs) and their connection to coronary heart disease (CHD) among Han Chinese with type 2 diabetes (T2D). <b>Methods:</b> The case-control research involved 781 individuals with T2D: 506 CHD cases and 275 controls. The tag-SNPs rs2266780, rs1736557, rs1800822, and rs909530 were selected according to the e!Ensembl database. The genotypes of all the research populations were analyzed via mass spectrometry. SPSS 25.0 software was used to analyze the associations between the selected SNPs and the risk of developing CHD. <b>Results:</b> The rs1800822 T allele frequency was lower in the CHD group than in the non-CHD group (<i>p</i> = 0.049), as was the rs909530 T allele frequency (<i>p</i> = 0.029). The carriers of rs909530 CX genotype had a greater risk of developing CHD than did the TT genotype carriers in the non-premature CHD group (<i>p</i> < 0.001). <b>Conclusion:</b> Our study revealed that rs1800822 and rs909530 in the FMO3 gene may be related to CHD risk among Han Chinese with T2D. We observed a significant gene-by-age interaction at rs909530 on CHD risk, indicating that aging modulates the effect of this locus. Young patients with T2D and the CX genotype may require more stringent management of cardiovascular risk factors.