A-not-full-blown Weil’s disease: An atypical cause of leptospirosis-induced acute hepatitis

Leptospirosis is a worldwide zoonotic disease caused by pathogenic Leptospira species. It usually manifests as an acute bacterial febrile septicemia like illness that affects both humans and animals. Human infection may occur via mucosal surfaces, abraded skin, or inhalation of aerosolized contaminated water. Liver involvement is a frequent finding in leptospirosis that ranges from mild dysfunction to severe icteric illness with renal failure. We herein present a case of acute hepatitis and febrile jaundice induced by Leptospirosis. The patient had cardiac involvement but no pulmonary or renal involvement, further adding ambiguity to the diagnosis. The diagnosis of leptospirosis in this case was particularly challenging due to its atypical presentation. The unusual constellation of findings underscores the importance of considering leptospirosis in the differential diagnosis of febrile jaundice, even in the absence of classical risk factors. The initiation of potentially life-saving antibiotic treatment requires a high index of clinical suspicion.