Canonical correlation analysis on the association between pulmonary function and obesity in early-onset COPD: CT-based body composition analysis
In summary, early-onset COPD patients with elevated BMI and VAT but reduced SAT exhibited improved pulmonary function across most parameters. This enhancement was not observed in MEF<sub>50</sub> and MEF<sub>25</sub>. In contrast, the non-COPD cohort exhibits overall respiratory enhancement, as the cross-loading coefficient of MEF25-an indicator reflecting the weight of a variable in contributing to the canonical variate-is extremely small (0.05) and has a negligible impact on the overall association.
Authors
- Tianye Li (ORCID: https://orcid.org/0000-0002-9422-5782)
- Zhenghao Chen (ORCID: https://orcid.org/0000-0002-7612-3694)
- Jiaru Shi (ORCID: https://orcid.org/0000-0002-2189-685X)
- Hongjun Zhao (ORCID: https://orcid.org/0000-0003-0263-7593)
- Lan Su (ORCID: https://orcid.org/0000-0001-8404-0680)
- Qian Wu (ORCID: https://orcid.org/0000-0002-7835-535X)
- Chengshui Chen
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Quzhou City People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fmed.2025.1633451
- Citations
- 1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Key Research and Development Program of China