Ischemic postconditioning ameliorates diabetic cerebral ischemia via activating the brain-derived neurotrophic factor–tropomyosin receptor kinase B–hypoxia-inducible factor 1α–Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 pathway to induce microg
IPOC coordinates microglial mitochondrial autophagy and astrocyte inflammatory regulation through the BDNF-TrkB-HIF-1α-BNIP3 signaling cascade, providing a new target for precise intervention in diabetes combined with cerebral ischemia.
Authors
- Tingyu Ke (ORCID: https://orcid.org/0000-0001-8848-5441)
- Shiying Huang (ORCID: https://orcid.org/0000-0002-0370-1553)
- Yuanyuan Han (ORCID: https://orcid.org/0000-0003-1507-0506)
- Ying Wang (ORCID: https://orcid.org/0000-0003-4524-1812)
- Ling Zhao (ORCID: https://orcid.org/0000-0001-9980-4903)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fendo.2025.1620004
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84