Identification of novel high-risk genes in gastric cancer through single-cell RNA sequencing, eQTL Mendelian randomization, and in vitro validation
Our study reveals previously unattended high-risk gastric cancer genes, potentially offering new directions and evidence for the molecular diagnosis and treatment of gastric cancer.
Authors
- Xinyu Hao (ORCID: https://orcid.org/0000-0002-1764-0499)
- Chen Wang
- Ningning Ren
- Pingping Zhou (ORCID: https://orcid.org/0000-0001-6368-3003)
- Kunfeng Li (ORCID: https://orcid.org/0000-0001-5788-6218)
- Xuetong Ren (ORCID: https://orcid.org/0000-0001-6151-1013)
- Tianyu Gao (ORCID: https://orcid.org/0000-0002-5722-9231)
- Yuhua Wang (ORCID: https://orcid.org/0000-0003-4311-5425)
- Wenbo Li (ORCID: https://orcid.org/0000-0003-4867-0479)
- Qi Li (ORCID: https://orcid.org/0000-0002-9422-3066)
- Haoyu Chen (ORCID: https://orcid.org/0000-0003-4606-9313)
- Yangang Wang (ORCID: https://orcid.org/0000-0003-1298-9963)
- Shaowei Liu (ORCID: https://orcid.org/0000-0003-2830-5159)
- Haiyan Bai
Institutions
- Hebei Medical University (CN)
- Beijing University of Chinese Medicine (CN)
- Peking University (CN)
- Hospital of Hebei Province (CN)
- Hebei University of Chinese Medicine (CN)
- Peking University Third Hospital (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Global Medical Genetics
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.gmg.2025.100077
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00