Proteoglycan 4 attenuates ischemic post-stroke hemorrhagic transformation and blood-brain barrier disruption
Recombinant PRG4 ameliorated post-stroke neurological impairment, HT, and BBB disruption. This finding identifies a biological function for PRG4 in stroke and provides support for therapeutic strategies targeting HT and BBB injury.
Authors
- Ruanxian Dai (ORCID: https://orcid.org/0009-0005-0169-8580)
- Qiang Meng (ORCID: https://orcid.org/0000-0002-6468-9121)
- Zhimin Li (ORCID: https://orcid.org/0000-0002-0988-9374)
- Shiyi Li (ORCID: https://orcid.org/0000-0002-1650-3249)
- Jiajie Chen (ORCID: https://orcid.org/0000-0001-9408-5030)
- Jing Yang (ORCID: https://orcid.org/0009-0008-2068-2658)
- Ning Tang (ORCID: https://orcid.org/0009-0002-9446-1344)
- Fengwen Jiang (ORCID: https://orcid.org/0009-0009-4206-5690)
Institutions
- Kunming University of Science and Technology (CN)
- Minzu University of China (CN)
- First People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.ibneur.2025.09.008
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Kunming Medical University
- Kunming University of Science and Technology