Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain
Our results emphasize the widespread presence of previously undetected RNA and protein isoforms in the human brain and provide an effective approach to address this knowledge gap. Uncovering the isoform repertoire of candidate neuropsychiatric risk genes will underpin future analyses of the functional impact these isoforms have on neuropsychiatric disorders, enabling the translation of genomic findings into a pathophysiological understanding of disease.
Authors
- Josie Gleeson (ORCID: https://orcid.org/0000-0002-4302-9191)
- Anran Li (ORCID: https://orcid.org/0000-0001-5031-4241)
- Benjamin L. Parker (ORCID: https://orcid.org/0000-0003-1818-2183)
- Mriga Dutt (ORCID: https://orcid.org/0000-0003-4240-1219)
- Yair D. J. Prawer (ORCID: https://orcid.org/0000-0002-4446-0733)
- Michael B. Clark (ORCID: https://orcid.org/0000-0002-2903-9537)
- Catriona McLean (ORCID: https://orcid.org/0000-0002-0302-5727)
- Shweta S Joshi (ORCID: https://orcid.org/0000-0003-2747-1331)
- Yupei You (ORCID: https://orcid.org/0000-0001-7302-3033)
- Ricardo De Paoli‐Iseppi (ORCID: https://orcid.org/0000-0001-7724-9144)
- Rhea Kujawa (ORCID: https://orcid.org/0009-0006-3937-6437)
- Ria Agarwal (ORCID: https://orcid.org/0009-0007-0376-753X)
- Yoonji Seo
- Raphael Chang
- Anthea Hull
- Eloise Marie Whitehead
Institutions
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Science for Life Laboratory (SE)
- Alfred Health (AU)
- Melbourne Genomics Health Alliance (AU)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- Genome biology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1186/s13059-025-03724-1
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Alliance for Research on Schizophrenia and Depression
- FightMND
- Medical Research Council
- National Health and Medical Research Council