Sex-Specific Effects of Hypocretin Receptor Signaling in Corticotropin-Releasing Factor Neurons on Alcohol Drinking, Anxiety, and Extended Amygdala Neuronal Excitability
These findings suggest that HCRT signaling in CRF neurons plays a critical role in the persistence of excessive alcohol consumption and the development of negative affective states, with distinct contributions from HcrtR1 and HcrtR2. The observed sex-specific differences underscore the need for tailored therapeutic approaches targeting the HCRT system in the treatment of AUD.
Authors
- Allison R. Morningstar (ORCID: https://orcid.org/0000-0002-3857-0450)
- Yihe Ma (ORCID: https://orcid.org/0000-0001-7825-0868)
- William J. Giardino (ORCID: https://orcid.org/0000-0001-7474-7914)
- Haniyyah Sardar
- Julie A. Kauer (ORCID: https://orcid.org/0000-0002-3362-1642)
- Anne Vassalli (ORCID: https://orcid.org/0000-0002-5314-5620)
- Max E. Benabou
- Isaac F. Kandil
- Angeline C. Yu
- Ethan T. Rogers (ORCID: https://orcid.org/0009-0000-3563-7149)
- Roosevelt Fajardo
Institutions
- Neurosciences Institute (US)
- University of Lausanne (CH)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100617
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Brain Research Foundation
- National Institutes of Health