Different mechanisms of axitinib and diazepam antiseizure action in pentylenetetrazol-induced kindling model
The antiseizure effect of tyrosine kinase B inhibition with a specific antagonist of VEGF axitinib is particularly pronounced in the early phase of PTZ kindling. Opposite to axitinib, diazepam demonstrated a similar antiseizure action in both periods of kindling. These results suggest a more pronounced contribution of angiogenesis compared with the neuronal degenerative hippocampal damage to the development of PTZ-kindled chronic epileptogenesis.
Authors
- Kıymet Kübra Tüfekci̇ (ORCID: https://orcid.org/0000-0002-4722-3813)
- L. S. Godlevsky (ORCID: https://orcid.org/0000-0003-0935-8255)
- Mykhailo Pervak (ORCID: https://orcid.org/0000-0002-0360-5756)
- Süleyman Kaplan (ORCID: https://orcid.org/0000-0003-1477-5002)
- Işınsu Alkan (ORCID: https://orcid.org/0000-0002-9819-7766)
Institutions
- Nevşehir Hacı Bektaş Veli University (TR)
- Odessa National Medical University (UA)
- Ondokuz Mayıs University (TR)
- Kastamonu University (TR)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.ibneur.2025.09.005
- Citations
- 1
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.49