Total hydrocortisone dosage in extremely low birth weight infants and neurodevelopment up to school age
As neonatal dexamethasone administration is known to affect neurodevelopment outcomes, hydrocortisone (HC) is considered an alternative to dexamethasone as a glucocorticoid treatment. In infants with extremely low birth weight (ELBW), a relationship has been noted between total HC dosage and neurodevelopment in early childhood. We confirmed the association between total HC dosage in infants with ELBW and poor developmental and intelligence quotients to school age. Although HC is commonly used in the management of ELBW infants, clinicians should be aware of its potential dose-dependent effects on neurodevelopmental outcomes.
Authors
- Basile Chrétien (ORCID: https://orcid.org/0000-0002-7483-2489)
- Eiko Kato (ORCID: https://orcid.org/0000-0001-6413-7135)
- Erina Kataoka (ORCID: https://orcid.org/0000-0003-2019-5346)
- Yuichiro Sugiyama (ORCID: https://orcid.org/0000-0001-5825-0991)
- Toshihiko Suzuki (ORCID: https://orcid.org/0000-0001-8760-1404)
- Miharu Ito (ORCID: https://orcid.org/0000-0001-7012-5974)
- Seiji Hayashi (ORCID: https://orcid.org/0009-0002-7893-5546)
- Ryuichi Tanaka (ORCID: https://orcid.org/0009-0006-7051-1035)
- Kazuto Ueda (ORCID: https://orcid.org/0000-0003-3297-024X)
- Akinobu Taniguchi (ORCID: https://orcid.org/0000-0002-6256-3146)
- Kazuki Nishida (ORCID: https://orcid.org/0000-0003-0367-8557)
- Takashi Maeda (ORCID: https://orcid.org/0000-0002-5133-8146)
- Hikaru Yamamoto (ORCID: https://orcid.org/0000-0001-7712-1095)
- Ryosuke Miura (ORCID: https://orcid.org/0009-0004-9198-9076)
- Yoshiaki Sato (ORCID: https://orcid.org/0000-0001-6320-9176)
- Yukako Muramatsu (ORCID: https://orcid.org/0000-0002-4503-9094)
- Koji Takemoto
Institutions
- Konan Kosei Hospital (JP)
- Nagoya University Hospital (JP)
- Toyota Memorial Hospital (JP)
- Okazaki City Hospital (JP)
- Ogaki Municipal Hospital (JP)
- Japanese Red Cross Nagoya Daiichi Hospital (JP)
- Anjo Kosei Hospital (JP)
- Tosei General Hospital (JP)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1038/s41390-025-04426-x
- Citations
- 1
- Primary Topic
- Infant Development and Preterm Care
- Type
- article
- Field-Weighted Citation Impact
- 3.49