Relationship between interleukin-6, coronary artery calcium and risk of heart failure: Insights from MESA
Combined elevation of IL-6 and CAC was associated with increased HFrEF risk, with significant additive and multiplicative interactions. For HFpEF, combined elevation conferred less risk than either alone. Inflammation modifies the CAC-HFrEF relationship and merits further study.
Authors
- Rishi Rikhi (ORCID: https://orcid.org/0000-0002-8013-4564)
- Leandro N. Slipczuk (ORCID: https://orcid.org/0000-0003-3091-3735)
- Michael D. Shapiro (ORCID: https://orcid.org/0000-0002-9071-3287)
- Moysés Szklo (ORCID: https://orcid.org/0000-0001-9433-6266)
- Muhammad Imtiaz Ahmad (ORCID: https://orcid.org/0000-0002-6870-1722)
- Saeid Mirzai (ORCID: https://orcid.org/0000-0002-2579-4965)
- Neha Jadeja Pagidipati (ORCID: https://orcid.org/0000-0002-5004-8868)
- Parag Anilkumar Chevli (ORCID: https://orcid.org/0000-0002-4084-8175)
Institutions
- Albert Einstein College of Medicine (US)
- Johns Hopkins University (US)
- Duke University (US)
- Medical College of Wisconsin (US)
- Montefiore Health System (US)
- Wake Forest University (US)
Publication Details
- Journal
- American Journal of Preventive Cardiology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.ajpc.2025.101310
- Citations
- 1
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.39