Fixed-dose vs loose-dose combination antidiabetic therapy and cardiorenal outcomes in type 2 diabetes: a nationwide comparative effectiveness study
FDC therapy in people with type 2 diabetes was associated with a lower rate of heart failure, particularly in older adults. Higher medication adherence appeared to mediate nearly half of this association.
Authors
- Paul I. Welsh (ORCID: https://orcid.org/0000-0002-7970-3643)
- Patrick Barry Mark (ORCID: https://orcid.org/0000-0003-3387-2123)
- Laura Pazzagli
- Jennifer Susan Lees (ORCID: https://orcid.org/0000-0001-6331-0178)
- Carlos Celis‐Morales (ORCID: https://orcid.org/0000-0003-2612-3917)
- Qiaoling Liu (ORCID: https://orcid.org/0000-0003-2109-3974)
Institutions
- Catholic University of the Maule (CL)
- Karolinska Institutet (SE)
- University of Glasgow (GB)
- Arturo Prat University (CL)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1186/s12933-025-02936-w
- Citations
- 2
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- AstraZeneca
- Wellcome Trust
- Novo Nordisk
- Astellas Pharma