High dietary phosphate intake induces anxiety in normal male mice
Collectively, this study highlights that habitual consumption of high dietary phosphate in mice may induce chronic anxiety<i>,</i> accompanied by significant changes in the neuronal and brain-resident immune populations. The data point to a potential link between dietary Pi, neuroinflammation, and the pathogenesis of anxiety and depression in otherwise healthy young male mice. Given the prevalence of phosphate additives in processed foods, these findings have important public health implications supporting the regulation of Pi in the food industry.
Authors
- Ann Stowe (ORCID: https://orcid.org/0000-0001-8111-4429)
- Charles Stuart (ORCID: https://orcid.org/0000-0001-5170-9026)
- R. Garcia Sturgill
- Pavel Yanev
- Noriyoshi Isozumi (ORCID: https://orcid.org/0000-0002-2077-7576)
- Han‐Kyul Kim (ORCID: https://orcid.org/0000-0003-1048-9543)
- Teppei Fujikawa (ORCID: https://orcid.org/0000-0002-4056-0526)
- Jadwiga Turchan‐Cholewo (ORCID: https://orcid.org/0000-0002-6831-2786)
- Shari G. Birnbaum (ORCID: https://orcid.org/0000-0001-9311-0310)
- Thomas A. Ujas (ORCID: https://orcid.org/0000-0001-8512-8369)
- Eiichiro Mori (ORCID: https://orcid.org/0000-0003-0945-196X)
- Wanpen Vongpatanasin (ORCID: https://orcid.org/0000-0002-7531-9388)
Institutions
- University of Kentucky (US)
- Osaka University of Human Sciences (JP)
- Southwestern Medical Center (US)
- Nara Medical University (JP)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.bbih.2025.101112
- Citations
- 1
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.91