Preclinical Immunogenicity Evaluation of a DTacP-sIPV/Hib Combination Vaccine in Rodent Models Under Varying Formulations and Immunization Schedules
The candidate DTacP-sIPV/Hib vaccine showed robust immunogenicity and flexibility across schedules and administration methods. A formulation including DT 12.5 Lf, TT 3.5 Lf, PT 25 μg, FHA 25 μg, PRN 8 μg, PRP 10 μg, and sIPV I/II/III at 30/32/45 DU is proposed for further development.
Authors
- Ping Ling (ORCID: https://orcid.org/0000-0002-9889-5812)
- Wei Huang (ORCID: https://orcid.org/0000-0001-9561-5099)
- Qiuyan Ji
- Jiana Wen
- Wenzhu Hu
- Hongwei Liao (ORCID: https://orcid.org/0000-0003-4799-5976)
- Guang Ji (ORCID: https://orcid.org/0000-0003-0842-3676)
- Xiaoyue He (ORCID: https://orcid.org/0000-0001-7311-0102)
- Lujie Yang (ORCID: https://orcid.org/0000-0003-0013-0529)
- Yunlong Fu
- Shengjie Ouyang
- Na Gao (ORCID: https://orcid.org/0000-0002-1831-8354)
- Jiangli Liang
- Yuting Fu (ORCID: https://orcid.org/0000-0002-8667-8298)
- Weimin Kong (ORCID: https://orcid.org/0000-0001-9591-5390)
- Qin Gu (ORCID: https://orcid.org/0000-0002-3722-6375)
- Mingqing Wang
- Guoyang Liao (ORCID: https://orcid.org/0000-0001-9566-9046)
- Yan Ma
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0003-2933-7582)
- Jingyan Li (ORCID: https://orcid.org/0000-0003-3264-468X)
- Chu Han (ORCID: https://orcid.org/0000-0001-5978-8304)
- Ting Zhao (ORCID: https://orcid.org/0000-0001-5102-0157)
- Lukui Cai
- Jingsi Yang (ORCID: https://orcid.org/0009-0004-5059-289X)
- Huang Zheng (ORCID: https://orcid.org/0009-0001-9892-5049)
- Xiaolin Qin
Institutions
- Yunnan University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Vaccines
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3390/vaccines13100993
- Citations
- 1
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39