Associations of Plasma and Urine Uromodulin With Kidney Disease Progression in Persons With Chronic Kidney Disease and Hypertension: The Systolic Blood Pressure Intervention Trial
Among persons with hypertension and CKD, plasma UMOD levels were associated with slower decline in eGFR and reduced risk of 30% eGFR decline after adjustment for demographic and clinical characteristics, whereas urine UMOD levels were not. When evaluating risk of kidney endpoints, plasma rather than urine may be the preferable specimen for UMOD measurement.
Authors
- Rebecca Scherzer (ORCID: https://orcid.org/0000-0002-1579-5390)
- Stein Hallan (ORCID: https://orcid.org/0000-0002-9045-3569)
- Ronit Katz (ORCID: https://orcid.org/0000-0001-7723-7469)
- Joachim H. Ix (ORCID: https://orcid.org/0000-0002-8084-9869)
- Pranav Sandilya Garimella (ORCID: https://orcid.org/0000-0002-6016-4715)
- Michelle M. Estrella (ORCID: https://orcid.org/0000-0002-8902-9576)
- Jesse C. Ikeme (ORCID: https://orcid.org/0000-0002-0341-8942)
- Michael G. Shlipak
Institutions
- University of Washington (US)
- Norwegian University of Science and Technology (NO)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- St Olav's University Hospital (NO)
- San Francisco VA Health Care System (US)
Publication Details
- Journal
- Kidney Medicine
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.xkme.2025.101118
- Citations
- 1
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 1.43