A sensitive 2D Cu-TCPP-based respiratory ammonia sensor for non-invasive and more accessible detection of <i>Helicobacter pylori</i> infection
This study created a sensitive Raman ammonia sensor using 2D Cu-TCPP nanosheets for noninvasive <i>H. pylori</i> detection. Leveraging multiple ammonia-binding sites and Au nanoparticle signal enhancement, it achieved a 1 ppm detection limit. Testing patients' breath, it identified <i>H. pylori via</i> ammonia levels, showing clear <i>I</i><sub>997</sub>/<i>I</i><sub>1030</sub> ratio shifts post-urea intake, offering a promising noninvasive diagnostic tool.
Authors
- Zhenxia Zhao (ORCID: https://orcid.org/0000-0003-2582-7082)
- Guangxi Li (ORCID: https://orcid.org/0000-0002-2234-9188)
- Ji‐Zheng He (ORCID: https://orcid.org/0000-0002-9169-8058)
- Miao Li (ORCID: https://orcid.org/0000-0003-3720-5336)
- Yiran Wang
- Min Li (ORCID: https://orcid.org/0000-0003-2959-9080)
- Lei Li (ORCID: https://orcid.org/0000-0001-5478-5681)
- Mingwan Su (ORCID: https://orcid.org/0000-0003-3597-5169)
Institutions
- Guangxi University (CN)
- Chinese Academy of Sciences (CN)
- Institute of High Energy Physics (CN)
- China Academy of Chinese Medical Sciences (CN)
- Guangxi Research Institute of Chemical Industry (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02047f
- Citations
- 1
- Primary Topic
- Gas Sensing Nanomaterials and Sensors
- Type
- article
- Field-Weighted Citation Impact
- 0.73