Type B Fibers: A Novel Ultrastructural Biomarker for Cognitive Impairment in Neuronal Intranuclear Inclusion Disease
The presence of two different forms of fibrils, type A and type B, in the inclusion bodies of NIID patients, and the poorer cognitive level of NIID patients in the type B group than that of type A suggest that type B fibrils can be used as a novel pathological marker of severe cognitive impairment and poor prognosis in NIID.
Authors
- Binbin Zhou (ORCID: https://orcid.org/0000-0003-3573-2263)
- Yangye Lian
- Luyao Huang (ORCID: https://orcid.org/0000-0003-4657-1442)
- Xin Wang (ORCID: https://orcid.org/0000-0001-7467-6060)
- Jing Ding (ORCID: https://orcid.org/0000-0002-0249-525X)
- Shaoping Zhong (ORCID: https://orcid.org/0000-0003-4133-1159)
- Jingzhen Liang
Institutions
- Fudan University (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Brain Sciences
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3390/brainsci15101026
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00