Infection and herbicide exposure implicate c-Abl kinase in α-Synuclein Ser129 phosphorylation
These findings highlight the pivotal role of c-Abl in α-Synucleinopathies and provide insights into shared mechanisms between infection and pesticide exposure, offering potential therapeutic targets for Parkinson's disease and related pathologies involving α-Synuclein modification.
Authors
- D Holthaus (ORCID: https://orcid.org/0000-0002-7012-5605)
- Anca Remes
- Saskia F. Erttmann (ORCID: https://orcid.org/0000-0003-2398-8405)
- Alvaro Quevedo-Olmos (ORCID: https://orcid.org/0000-0002-4137-7045)
- Oliver Josef Müller (ORCID: https://orcid.org/0000-0001-8223-2638)
- Nina Hedemann (ORCID: https://orcid.org/0000-0002-8222-1063)
- Marzieh Ehsani (ORCID: https://orcid.org/0009-0007-4412-7846)
- Thomas F. Meyer (ORCID: https://orcid.org/0000-0002-6120-8679)
- Mahdi Rasa
- Zeyang Sun
- Gesa Rösler
Institutions
- Xuzhou Medical College (CN)
- Nantong University (CN)
- Christian-Albrechts-Universität zu Kiel (DE)
- Max Planck Institute for Infection Biology (DE)
- University Hospital Schleswig-Holstein (DE)
- Yancheng First People's Hospital (CN)
- Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1186/s12964-025-02399-2
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Max-Planck-Gesellschaft
- China Scholarship Council