Gastrin-dependent expansion of Cck2r <sup>+</sup> corpus progenitors accelerates ulcer healing and inhibits gastric dysplasia
We report a novel role for G-cell-derived gastrin in ulcer healing. Hypogastrinaemia is a risk factor for poor ulcer healing, corpus atrophy and potentially cancer, while physiological gastrin responses are protective. PPI-induced hypergastrinaemia plays a key role in ulcer healing, and gastrin signalling may prevent gastric preneoplasia.
Authors
- Xiaofei Zhi (ORCID: https://orcid.org/0000-0003-1367-7638)
- Biyun Zheng (ORCID: https://orcid.org/0000-0001-7680-8661)
- Quin T. Waterbury (ORCID: https://orcid.org/0000-0001-6394-9895)
- Jin Qian
- Masahiro Hata (ORCID: https://orcid.org/0000-0002-3836-3515)
- Fenglin Chen (ORCID: https://orcid.org/0000-0001-6369-6998)
- Leah Zamechek (ORCID: https://orcid.org/0000-0003-2863-2950)
- Jinsong Lu
- Guodong Lian
- Ermanno Malagola (ORCID: https://orcid.org/0000-0001-9294-3097)
- Hiroki Kobayashi (ORCID: https://orcid.org/0000-0002-1717-4870)
- Feijing Wu (ORCID: https://orcid.org/0000-0001-9198-7960)
- Ru‐Hong Tu (ORCID: https://orcid.org/0000-0002-7491-3879)
- Puran Zhang (ORCID: https://orcid.org/0000-0002-8757-3535)
- Shuang Li (ORCID: https://orcid.org/0000-0002-9193-0320)
- Yi Zeng (ORCID: https://orcid.org/0000-0002-5477-6686)
- Xiaozhong Wang (ORCID: https://orcid.org/0000-0001-8152-8971)
- Kexuan Huang
- Hua‐Long Zheng (ORCID: https://orcid.org/0000-0002-2749-0113)
- Yosuke Ochiai
Institutions
- Fujian Medical University (CN)
- Nantong University (CN)
- Columbia University Irving Medical Center (US)
- Affiliated Hospital of Nantong University (CN)
- Shandong Provincial Hospital (CN)
- Fujian Provincial Cancer Hospital (CN)
- Shandong First Medical University (CN)
- Union Hospital (CN)
- Columbia University (US)
Publication Details
- Journal
- Gut
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1136/gutjnl-2025-335103
- Citations
- 1
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01