HyperArc Automated Stereotactic Radiosurgery Planning Enables Accurate a Priori Fractionation Scheme Selection via Adherence to HyTEC Toxicity Thresholds
The resulting models enabled accurate and precise prediction of target volumes/diameters, resulting in 3.6%, 4.8%, and 8.6% brain grade 1 to 3 toxicity rates, according to HyTEC toxicity estimates. Leveraging relative IDVs rather than prescription doses enabled all 3361 targets to be used for modeling 9 common SRS prescriptions (1 fx: 24 Gy, 20 Gy, 18 Gy, 16 Gy, and 15 Gy; 3 fx: 27 Gy and 24 Gy; 5 fx: 30 Gy and 25 Gy), enabling clinicians to estimate brain toxicity a priori via an open-source calculator.
Authors
- Joel A. Pogue (ORCID: https://orcid.org/0000-0003-4450-6698)
- R Cardan (ORCID: https://orcid.org/0000-0001-9483-1398)
- Richard A. Popple (ORCID: https://orcid.org/0000-0003-1252-738X)
- Christopher Willey
- Philip Schmalz
- Samuel Marcrom (ORCID: https://orcid.org/0000-0002-4014-3781)
- James M. Markert (ORCID: https://orcid.org/0000-0001-7457-7329)
- Natalie Viscariello
- Rodney J. Sullivan
- John B. Fiveash (ORCID: https://orcid.org/0000-0002-1129-2884)
- Luke Moradi (ORCID: https://orcid.org/0000-0002-8055-6388)
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.adro.2025.101893
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00