Isolated laryngeal amyloidosis in a child: A rare case report

Background: Laryngeal amyloidosis is a rare cause of hoarseness, particularly in pediatric patients. While more commonly seen in adults, isolated laryngeal involvement without systemic disease is exceedingly rare in children. Case presentation: We report a case of a 10-year-old female who presented with a six-month history of progressive dysphonia. Laryngoscopic examination revealed suspicious lesions, and biopsy confirmed amyloid deposition. Systemic workup by pediatric rheumatology was unremarkable, confirming a diagnosis of isolated laryngeal amyloidosis. The patient underwent surgical intervention for symptom relief and was scheduled for regular follow-up due to the potential for recurrence. Conclusion: Isolated laryngeal amyloidosis should be considered in the differential diagnosis of persistent dysphonia in children. Early recognition and biopsy are crucial for diagnosis, and long-term follow-up is recommended given the potential for recurrence.