Transgenic Models to Study Angiogenesis and Lymphangiogenesis: An Historical Note

The knockout mouse has been a valuable tool for geneticists to discern the role of a gene in embryonic development and in normal physiological homeostasis. The development of transgenic technologies in mice has allowed the study of the consequences of genetic alterations on angiogenesis and lymphangiogenesis. This historical review article summarizes the first literature evidence concerning the use of transgenic models to study the most important factors involved in the regulation of angiogenesis and lymphangiogenesis.