No differences in therapeutic efficacy while sparing healthy tissue for orthotopic glioblastoma patient-derived xenografts in context of proton FLASH
Ultra-high dose rate (FLASH-RT) and conventional proton beam radiotherapy to intracranial glioblastoma PDX were compared for tumor control and normal tissue toxicity via DNA and RNA damage response markers. Both conventional and FLASH radiotherapy yielded similar survival benefits; however, conventional radiotherapy resulted in greater normal tissue DNA and RNA damage.
Authors
- Andee M. Beierle
- Lauren Nassour (ORCID: https://orcid.org/0000-0003-4096-9716)
- Joshua C. Anderson (ORCID: https://orcid.org/0000-0002-6977-9054)
- Taylor L. Schanel
- Manoj Kumar (ORCID: https://orcid.org/0000-0001-7270-7898)
- R Cardan (ORCID: https://orcid.org/0000-0001-9483-1398)
- Anita B. Hjelmeland (ORCID: https://orcid.org/0000-0003-2200-3248)
- Sreelakshmi Cherakara (ORCID: https://orcid.org/0000-0003-2617-3236)
- Christopher D. Willey (ORCID: https://orcid.org/0000-0001-9953-0279)
- Rajiv Pandit
- Patricia H. Hicks
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.ctro.2025.101050
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00