Alleviated T cell exhaustion and SLC1A3-mediated stroma-remodelling dictate chemoimmunotherapy efficacy in oesophageal squamous cell carcinoma
This study elucidates the synergistic mechanisms and identifies key resistance pathways underlying chemo-immunotherapy combinations in patients with ESCC, providing a scientific basis for refining future combination therapeutic regimens.
Authors
- Yanxing Chen (ORCID: https://orcid.org/0000-0001-6346-9752)
- Min Wang (ORCID: https://orcid.org/0000-0003-2985-0589)
- Zhigang Li (ORCID: https://orcid.org/0000-0001-5086-5334)
- Qi Zhao (ORCID: https://orcid.org/0000-0002-8683-6145)
- Lu-Ping Yang (ORCID: https://orcid.org/0000-0003-4697-6853)
- Feng Wang (ORCID: https://orcid.org/0000-0001-7668-9674)
- Chaoye Wang (ORCID: https://orcid.org/0000-0003-1987-777X)
- Shaoyan Xi (ORCID: https://orcid.org/0000-0002-7223-1858)
- Jinling Zhang (ORCID: https://orcid.org/0000-0003-3419-6542)
- Zhichao Liu (ORCID: https://orcid.org/0000-0003-3542-0905)
- Zi-Xian Wang
- Ye He
- Qi-Nian Wu
- Siyu Xiang (ORCID: https://orcid.org/0009-0004-9732-8156)
- Wei Yu (ORCID: https://orcid.org/0000-0002-9672-3849)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai Chest Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1136/gutjnl-2025-335642
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00