The active constituent of pine needle oil, bornyl acetate, suppresses NSCLC progression by inhibiting the PI3K/AKT/ABCB1 signaling axis
These results demonstrate that BA exerts potent anti-tumor effects in NSCLC by inhibiting the PI3K/AKT/ABCB1 axis. The findings provide a mechanistic rationale for the development of BA and other natural product-based therapies, particularly for the treatment of drug-resistant NSCLC.
Authors
- Zeyang Yang (ORCID: https://orcid.org/0000-0003-0489-9132)
- Yu Cao (ORCID: https://orcid.org/0000-0003-2139-2114)
- Xinlei Liu (ORCID: https://orcid.org/0009-0000-0139-349X)
- Jieheng Wu (ORCID: https://orcid.org/0000-0003-4927-3897)
- Xuanyin Wang (ORCID: https://orcid.org/0000-0002-6052-5015)
- Jiaming Ren
- Yaxuan Cao
- Lu Wang (ORCID: https://orcid.org/0000-0002-0073-0666)
- Long Li (ORCID: https://orcid.org/0000-0002-5906-8777)
- Xu Zhu (ORCID: https://orcid.org/0000-0001-9300-4307)
- Lu Ma (ORCID: https://orcid.org/0000-0002-7599-7920)
- Jinyi Wu (ORCID: https://orcid.org/0000-0002-1601-1084)
- Z. Tu (ORCID: https://orcid.org/0009-0009-1895-480X)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-5476-1524)
- Ye Wang (ORCID: https://orcid.org/0000-0002-5383-2690)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Guiyang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fphar.2025.1653461
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guizhou Medical University