Biomarkers of Alzheimer’s disease modification using adaptive cognitive assessments to improve responsiveness—a simulation study
ACA can increase biomarker responsiveness to treatment effects over fixed difficulty. ACA deployment should be guided by study and assessment features, including duration, expected cognitive decline rates and effect size. In the high-dimensional parameter space of ACA instruments, study simulations are indispensable to identify suitable deployment strategies.
Authors
- Corrado Bernasconi (ORCID: https://orcid.org/0000-0002-1019-5468)
- Silvan Pless (ORCID: https://orcid.org/0000-0002-9660-9077)
- A. B. Rodriguez-Romero (ORCID: https://orcid.org/0000-0002-9752-8156)
- Shibeshih Mitiku Belachew (ORCID: https://orcid.org/0000-0003-3976-1950)
- Óscar Reyes (ORCID: https://orcid.org/0000-0003-0169-297X)
- Claudia Mazzà (ORCID: https://orcid.org/0000-0002-5215-1746)
- E Bartholomé (ORCID: https://orcid.org/0009-0007-1370-8197)
- C. Lucena Luque
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fnins.2025.1653261
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00