Mechanistic studies of miR-582-3p targeting of PTPRCAP affecting lung adenocarcinoma via the Wnt/β-catenin pathway
Our findings reveal a novel <i>miR</i>-582-3p/<i>PTPRCAP</i>/Wnt/β-catenin axis in LUAD progression, where <i>miR</i>-582-3p drives tumor growth by silencing <i>PTPRCAP</i> and activating Wnt signaling. These results highlight <i>miR</i>-582-3p as a potential therapeutic target and <i>PTPRCAP</i> as a tumor suppressor in LUAD, offering new insights for targeted intervention strategies.
Authors
- Zongying Liang
- Pengfei Guo (ORCID: https://orcid.org/0000-0002-4618-6803)
- Song Zhao (ORCID: https://orcid.org/0000-0002-2095-7956)
- Xiaoli Han (ORCID: https://orcid.org/0000-0002-4297-8934)
- Yuting Yang (ORCID: https://orcid.org/0000-0001-6897-3130)
- Baoshan Zhao (ORCID: https://orcid.org/0000-0003-1583-3083)
Institutions
- Chengde Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fonc.2025.1652176
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00