Acute pontine infarction inducing REM sleep behavior disorder: a novel case report

Rapid eye movement (REM) sleep behavior disorder (RBD) is parasomnia characterized by the loss of physiological muscle atonia during REM sleep, resulting in dream-enacting behaviors that often manifest as complex, violent motor activity. While RBD may occur idiopathically, it is frequently associated with neurodegenerative disorders, particularly <i>α</i>-synucleinopathies such as Parkinson's disease. However, secondary RBD linked to acute cerebrovascular events remains poorly documented. Here, we present a novel case of acute pontine infarction precipitating RBD, highlighting the brainstem's critical role in REM sleep regulation and expanding the spectrum of secondary RBD etiologies. This case report underscores the importance of neuroanatomical localization in evaluating acute-onset RBD, particularly in the context of cerebrovascular pathology.

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Publication Details

Journal
Frontiers in Human Neuroscience
Published
2025-09-23
DOI
https://doi.org/10.3389/fnhum.2025.1614797
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
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article

Acute pontine infarction inducing REM sleep behavior disorder: a novel case report

Hong Wang, Liuqing Wang
Frontiers in Human Neuroscience
Sleep and Wakefulness Research
article

Acute pontine infarction inducing REM sleep behavior disorder: a novel case report

Hong Wang, Liuqing Wang
article en

Abstract

Rapid eye movement (REM) sleep behavior disorder (RBD) is parasomnia characterized by the loss of physiological muscle atonia during REM sleep, resulting in dream-enacting behaviors that often manifest as complex, violent motor activity. While RBD may occur idiopathically, it is frequently associated with neurodegenerative disorders, particularly <i>α</i>-synucleinopathies such as Parkinson's disease. However, secondary RBD linked to acute cerebrovascular events remains poorly documented. Here, we present a novel case of acute pontine infarction precipitating RBD, highlighting the brainstem's critical role in REM sleep regulation and expanding the spectrum of secondary RBD etiologies. This case report underscores the importance of neuroanatomical localization in evaluating acute-onset RBD, particularly in the context of cerebrovascular pathology.

Frontiers in Human NeuroscienceVol. 19
Wenzhou Medical University (CN), First Affiliated Hospital of Wenzhou Medical University (CN), Gaochun People's Hospital (CN)
Openalex Percentile: Top 74%
Sleep and Wakefulness Research
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Acute pontine infarction inducing REM sleep behavior disorder: a novel case report — Hong Wang, Liuqing Wang · Frontiers in Human Neuroscience (2025) | TGRS Research Map | TGRS