Kappa free light chain index as a diagnostic and prognostic biomarker in multiple sclerosis
The KFLC index shows diagnostic utility comparable to OCB; however, it is an adjunctive biomarker that complements clinical and MRI findings and should not be used as a standalone diagnostic test. An elevated KFLC index was associated with short-term accrual of infratentorial or SC lesions; these exploratory findings require validation in larger, longer-term cohorts.
Authors
- Ángel Pérez Sempere (ORCID: https://orcid.org/0000-0002-0195-2834)
- Luis Moreno-Navarro (ORCID: https://orcid.org/0000-0002-7550-6239)
- Lourdes Ruiz-Escribano-Menchen (ORCID: https://orcid.org/0000-0003-0746-1005)
- Sergio Mora-Diaz (ORCID: https://orcid.org/0000-0002-4646-0729)
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- University of Alicante (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1007/s00415-025-13381-w
- Citations
- 2
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94