High dose of psilocybin induces acute behavioral changes without inducing conditioned place preference in Sprague-Dawley rats
Psilocybin at this regimen (10 mg/kg, every other day) does not induce CPP, but induces changes in behavior, which disappear 48 hours after the last injection. More research is needed to better evaluate the addiction liability of psychedelics using different paradigms, doses, and protocols.
Authors
- Tânia Marcourakis (ORCID: https://orcid.org/0000-0002-0076-5017)
- Gabriella Gobbi (ORCID: https://orcid.org/0000-0003-4124-9825)
- Vítor Bruno (ORCID: https://orcid.org/0000-0002-1092-523X)
- Brandon Richardson (ORCID: https://orcid.org/0000-0002-0325-9216)
- Rosana Camarini (ORCID: https://orcid.org/0000-0002-8131-6108)
- Martha López-Canul
Institutions
- Universidade de São Paulo (BR)
- McGill University Health Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1177/02698811251368361
- Citations
- 2
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.61