Integrated mRNA-seq and miRNA-seq analysis reveals miR-210a-5p regulates uterine aging in laying hens by targeting the RASL11B/Raf/MAPK pathway
This study identifies a novel regulatory pathway in which miR-210a-5p modulates uterine aging through the RASL11B-MAPK signaling cascade. The findings provide mechanistic insight into age-related reproductive decline in hens and suggest that targeting this pathway may offer new strategies for maintaining uterine function and extending reproductive lifespan in poultry.
Authors
- Xiyu Zhao
- Conghao Zhong (ORCID: https://orcid.org/0000-0003-0063-4970)
- Shunshun Han (ORCID: https://orcid.org/0000-0001-9394-1165)
- Huadong Yin (ORCID: https://orcid.org/0000-0001-9132-3603)
- Xinyan Li (ORCID: https://orcid.org/0000-0003-4514-5695)
- Yao Zhang (ORCID: https://orcid.org/0000-0001-9314-5820)
- Wenxin Zhang (ORCID: https://orcid.org/0000-0002-2516-0954)
- Congjiao Sun (ORCID: https://orcid.org/0000-0002-9673-9533)
- Boxuan Zhang
- Mengfei Gao (ORCID: https://orcid.org/0000-0002-2836-4610)
Institutions
- Ministry of Agriculture (EE)
- China Agricultural University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1186/s40104-025-01257-y
- Citations
- 2
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.59