FAM111B enhances glycolysis and promotes metastasis of prostate cancer by upregulating LDHA
The high expression of FAM111B is associated with adverse clinical features of PCa. FAM111B protein binds to and hydrolyzes P27 protein, which activates Cyclin-CDKs/RB/E2F1 signaling pathway to increase LDHA expression, thereby enhancing the glycolytic ability and ultimately promoting the metastasis of PCa and may potentially serve as new targets for the treatment of metastatic PCa.
Authors
- Ying Ju (ORCID: https://orcid.org/0000-0003-3491-9915)
- Fang Lv (ORCID: https://orcid.org/0000-0002-1872-781X)
- Chuxiong Wang (ORCID: https://orcid.org/0009-0002-4414-4260)
- Yifei Xing (ORCID: https://orcid.org/0000-0002-5303-9633)
- Qingliu He
- Yarong Song (ORCID: https://orcid.org/0000-0003-0032-813X)
- Zehao Yu (ORCID: https://orcid.org/0000-0002-7290-8005)
- Haoran Li (ORCID: https://orcid.org/0000-0001-5108-9218)
- Liang Chen (ORCID: https://orcid.org/0000-0001-5845-2235)
- Pu Zhang (ORCID: https://orcid.org/0000-0001-8389-6196)
- Kang Chen (ORCID: https://orcid.org/0000-0001-9892-3118)
- Jinyu Chen (ORCID: https://orcid.org/0009-0002-7444-2963)
- Xuechao Li (ORCID: https://orcid.org/0000-0002-7088-3764)
- Lulin Cheng
- Yukun Cong
Institutions
- Fujian Medical University (CN)
- University of Electronic Science and Technology of China (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Neoplasia
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.neo.2025.101227
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94