NGAL knockdown alleviated CSE-induced cellular senescence and reduced MMP2 and MMP9 expression in alveolar macrophages through the PI3K/Akt pathway
These findings indicate that CSE upregulates NGAL in alveolar macrophages, thereby driving cellular senescence and MMP production through PI3K/Akt pathway.
Authors
- Jing Wang (ORCID: https://orcid.org/0000-0001-7145-8447)
- Yufeng Zheng (ORCID: https://orcid.org/0000-0002-7402-9979)
- Yong‐Xia Wang (ORCID: https://orcid.org/0000-0002-0870-4200)
- Chengji Jin
Institutions
- Hainan Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1186/s40001-025-03222-x
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hainan Province