Reducing effects of isoliquiritigenin, a naturally occurring GABAB receptor agonist, on alcohol-motivated behaviors in alcohol-preferring rats
These results confirm the ability of ISL to behave in vivo as a GABA<sub>B</sub> receptor agonist; they also indicate that ISL reproduced the suppressing effects of the prototypic GABA<sub>B</sub> receptor agonist, baclofen, on multiple alcohol-related behaviors in rodents.
Authors
- Giancarlo Colombo (ORCID: https://orcid.org/0000-0002-0194-8149)
- Gian Luigi Gessa
- Federico Corelli (ORCID: https://orcid.org/0000-0002-5750-4504)
- Paola Maccioni (ORCID: https://orcid.org/0000-0001-9071-0636)
- Mauro A.M. Carai (ORCID: https://orcid.org/0000-0003-3526-6899)
- Laura Regonini Somenzi
Institutions
- University of Siena (IT)
- University of Cagliari (IT)
- Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari (IT)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1007/s00213-025-06892-x
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00