Discovery of a DNA methylation episignature as a molecular biomarker for fetal alcohol syndrome
This study demonstrates that unique DNAm profiles provide a robust episignature biomarker for FAS. These findings contribute to the molecular understanding of FAS and hold promise for improving diagnostic accuracy for this complex disorder.
Authors
- Marcel M. A. M. Mannens (ORCID: https://orcid.org/0000-0001-7137-119X)
- Irene Valenzuela (ORCID: https://orcid.org/0000-0003-2350-6058)
- Mieke M. van Haelst (ORCID: https://orcid.org/0000-0001-7126-2030)
- Anna M. Cueto‐González (ORCID: https://orcid.org/0000-0001-7694-6124)
- Mariëlle Alders (ORCID: https://orcid.org/0000-0002-7386-4868)
- Jennifer Kerkhof (ORCID: https://orcid.org/0000-0003-1245-6606)
- Amaia Lasa‐Aranzasti (ORCID: https://orcid.org/0000-0002-9136-5106)
- Raissa Relator (ORCID: https://orcid.org/0000-0002-8153-2222)
- Adri N. Mul (ORCID: https://orcid.org/0000-0003-1189-4700)
- Peter Henneman (ORCID: https://orcid.org/0000-0003-2179-7808)
- Liselot van der Laan (ORCID: https://orcid.org/0000-0002-7800-8665)
- Bekim Sadiković (ORCID: https://orcid.org/0000-0001-6363-0016)
- Eduardo F. Tizzano (ORCID: https://orcid.org/0000-0002-7116-6310)
- Cristina Cea-Arestin
- Michael A. Levy (ORCID: https://orcid.org/0000-0002-4188-2527)
- Jessica Rzasa
Institutions
- Hebron University (PS)
- Western University (CA)
- London Health Sciences Centre (CA)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Genetics in Medicine
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.gim.2025.101586
- Citations
- 1
- Primary Topic
- Prenatal Substance Exposure Effects
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Genome Canada
- Ontario Genomics
- Amsterdam University Medical Centers
- Government of Canada
- Ontario Genomics Institute