The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
FOLFIRI response biomarkers in mCRC are lacking. Evidence in patient-derived xenografts, tumoroids, and patients shows that chemosensitivity arises from functional relaxation, rather than (epi)genetic inactivation, of the HR DNA repair pathway. Integrative analyses yield a chemopredictive algorithm centered on the expression of the RAD51 recombinase, with potential to refine patient stratification.
Authors
- Maria Nieva (ORCID: https://orcid.org/0009-0004-8742-4734)
- Clara Montagut (ORCID: https://orcid.org/0000-0003-1438-2903)
- Sara E. Bellomo (ORCID: https://orcid.org/0000-0001-5738-2351)
- Francesco Galimi (ORCID: https://orcid.org/0000-0002-5939-6922)
- Valter Torri (ORCID: https://orcid.org/0000-0001-9541-9354)
- Marco Avolio (ORCID: https://orcid.org/0000-0002-2822-8141)
- Marco Viviani (ORCID: https://orcid.org/0000-0003-4698-8870)
- Martina Ferri (ORCID: https://orcid.org/0000-0003-4010-8166)
- Josep M. Tabernero (ORCID: https://orcid.org/0000-0002-2495-8139)
- Gianluca Mauri (ORCID: https://orcid.org/0000-0002-7646-0973)
- Valentina Vurchio (ORCID: https://orcid.org/0000-0002-8699-2164)
- Enrico Berrino (ORCID: https://orcid.org/0000-0001-6728-5619)
- Irene Catalano (ORCID: https://orcid.org/0000-0002-3895-5860)
- Eugenia R. Zanella (ORCID: https://orcid.org/0000-0002-8036-3789)
- Felice Borghi (ORCID: https://orcid.org/0000-0002-2431-2020)
- Simonetta M. Leto (ORCID: https://orcid.org/0000-0001-7580-6584)
- Andrea Sartore‐Bianchi (ORCID: https://orcid.org/0000-0003-0780-0409)
- Élena Elez (ORCID: https://orcid.org/0000-0002-4653-6324)
- Salvatore Siena (ORCID: https://orcid.org/0000-0002-2681-2846)
- Andrea Bertotti (ORCID: https://orcid.org/0000-0001-8196-7608)
- Paolo Luraghi (ORCID: https://orcid.org/0000-0003-2379-5195)
- Alberto Sogari (ORCID: https://orcid.org/0000-0003-0612-6109)
- Livio Trusolino (ORCID: https://orcid.org/0000-0002-6379-3365)
- Elena Grassi (ORCID: https://orcid.org/0000-0003-1066-927X)
- Federica Tosi (ORCID: https://orcid.org/0000-0001-6146-7411)
- Noelia Tarazona (ORCID: https://orcid.org/0000-0003-4888-1655)
- Alberto Bardelli (ORCID: https://orcid.org/0000-0003-1647-5070)
- Francesco Sassi (ORCID: https://orcid.org/0000-0002-4741-0408)
- Caterina Marchiò (ORCID: https://orcid.org/0000-0003-2024-6131)
- Francesca Cottino (ORCID: https://orcid.org/0000-0001-6715-1784)
- Silvia Marsoni (ORCID: https://orcid.org/0000-0002-5361-7122)
- Petros Tsantoulis (ORCID: https://orcid.org/0000-0003-3613-6682)
- Barbara Lupo (ORCID: https://orcid.org/0000-0002-4383-6882)
- Luca Lazzari (ORCID: https://orcid.org/0000-0001-6841-4240)
- Federica Cruciani (ORCID: https://orcid.org/0000-0001-7258-1463)
- Andrés Cervantes (ORCID: https://orcid.org/0000-0003-3806-3691)
- Sabine Tejpar
Institutions
- University of Geneva (CH)
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Hebron University (PS)
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- HES-SO Genève (CH)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Hospital Clínico Universitario de Valencia (ES)
- 5T Torino (Italy) (IT)
- Vall d'Hebron Institut de Recerca (ES)
- IFOM (IT)
- Vall d'Hebron Hospital Universitari (ES)
- Torino e-district (IT)
- Department of Medical Sciences (BY)
- Hospital Del Mar (ES)
- Candiolo Cancer Institute (IT)
- INCLIVA Health Research Institute (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Vall d'Hebron Institute of Oncology (ES)
- University of Turin (IT)
- KU Leuven (BE)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0556
- Citations
- 1
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81