<i>In vitro</i> exposure to clofazimine can select for delamanid and pretomanid resistance in <i>Mycobacterium tuberculosis</i>
<i>In vitro</i> experiments with <i>Mycobacterium tuberculosis</i> showed that clofazimine exposure selected for delamanid and pretomanid resistance and mutations in <i>fbiA</i>, <i>fbiC</i>, or <i>fbiD</i>-after the acquisition of <i>Rv0678</i> mutations where this could be determined. Whether this is also possible <i>in vivo</i> and in an <i>Rv0678</i> wild-type background has to be studied further. Based on the available evidence, however, we propose that nitroimidazole resistance should not be considered an exclusion criterion for the use of clofazimine.
Authors
- Jens Vereecken (ORCID: https://orcid.org/0009-0001-9181-7053)
- Thomas Schön (ORCID: https://orcid.org/0000-0003-4849-1286)
- Thabisile Gwala (ORCID: https://orcid.org/0000-0002-7668-1178)
- Lavania Joseph (ORCID: https://orcid.org/0000-0003-0734-7149)
- Robin M. Warren (ORCID: https://orcid.org/0000-0001-5741-7358)
- Emanuele Borroni (ORCID: https://orcid.org/0000-0001-6780-5119)
- Leen Rigouts (ORCID: https://orcid.org/0000-0003-3301-9480)
- Claudio U. Köser (ORCID: https://orcid.org/0000-0002-0232-846X)
- Bouke C. de Jong (ORCID: https://orcid.org/0000-0002-1017-4675)
- Praharshinie Rupasinghe (ORCID: https://orcid.org/0000-0002-9858-8935)
- Shaheed Vally Omar (ORCID: https://orcid.org/0000-0001-6983-1636)
- Wim Mulders (ORCID: https://orcid.org/0000-0002-9566-3653)
- Paolo Miotto (ORCID: https://orcid.org/0000-0003-4610-2427)
- Daniela María Cirillo (ORCID: https://orcid.org/0000-0001-6415-1535)
- Nabila A. Ismail (ORCID: https://orcid.org/0000-0002-2287-1857)
- Dumisani Ngcamu (ORCID: https://orcid.org/0000-0002-9402-8615)
Institutions
- Linköping University (SE)
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
- Vita-Salute San Raffaele University (IT)
- University of Cambridge (GB)
- Stellenbosch University (ZA)
- Research Institute for Tropical Medicine (PH)
- Institut thématique Immunologie, inflammation, infectiologie et microbiologie (FR)
- Biology of Infection (FR)
- Landstinget i Kalmar län (SE)
- Linköping University Hospital (SE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Instituut voor Tropische Geneeskunde (BE)
- Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures (DE)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1128/aac.01113-25
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- South African Medical Research Council
- Medical Research Council