Global phylogeography and genomic characterization of <i>bla</i> <sub>NDM-1</sub> -positive clinical <i>Proteus mirabilis</i> isolates from China
To date, the phylogeographic distribution of <i>bla</i><sub>NDM</sub>-carrying CRPMs has not been determined. Our study identified ST135 as the predominant <i>bla</i><sub>NDM</sub>-producing clone, with a distinct global distribution pattern of NDM variants. Furthermore, we elucidated critical <i>bla</i><sub>NDM-1</sub> transmission mechanisms, revealing both plasmid- and SGI1-mediated dissemination and IS<i>CR1</i>-driven gene amplification, while also characterizing a novel SGI1-PM16 variant. These findings provide significant new insights into the molecular mechanisms underlying acquired antimicrobial resistance.
Authors
- Yunsong Yu (ORCID: https://orcid.org/0000-0003-2903-918X)
- Lingchen Yang (ORCID: https://orcid.org/0000-0001-5016-2284)
- Linyue Zhang (ORCID: https://orcid.org/0000-0002-0623-4727)
- Hongyin Yang (ORCID: https://orcid.org/0000-0002-7078-7705)
- Xuzhong Zuo (ORCID: https://orcid.org/0000-0002-1047-0095)
- Xi Li (ORCID: https://orcid.org/0000-0002-8838-7814)
- Qi Yan
- Haotian Xu (ORCID: https://orcid.org/0000-0003-3193-8432)
- Hongyan Yu (ORCID: https://orcid.org/0000-0002-3098-7104)
- Chengjin Wu
- Jingyi Guo
Institutions
- Zhejiang Chinese Medical University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Research Institute of Precision Instruments (Russia) (RU)
- Zoucheng People's Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- mSystems
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1128/msystems.00758-25
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18