Parahydrogen-Based Hyperpolarization for the Masses at Millitesla Fields

Hyperpolarization (HP) techniques, such as Parahydrogen-Induced Polarization (PHIP), Signal Amplification by Reversible Exchange (SABRE), and dissolution Dynamic Nuclear Polarization (d-DNP), significantly enhance the sensitivity of nuclear magnetic resonance (NMR) spectroscopy for chemical analysis and metabolic imaging. However, the high cost of equipment, ranging from tens of thousands to millions of dollars, limits accessibility of hyperpolarization for the broad scientific community. In this work, we aim to mitigate some of the challenges by developing a cost-effective solution for parahydrogen (pH2)-based PHIP and SABRE HP methods. A custom coil-winding machine was designed to fabricate solenoid magnet coils, which were then evaluated for their magnetic field profiles, demonstrating a high degree of magnetic field homogeneity. A model 1H SABRE experiment successfully implemented the constructed solenoid, achieving efficient hyperpolarization. Additionally, the solenoid magnet can be utilized for in situ detection of hyperpolarization when integrated with a low-field NMR spectrometer, reducing the total setup cost to a few thousand dollars. These findings suggest that our approach makes HP technology more affordable and accessible, potentially broadening its applications in chemical and biomedical research, as well as educational settings involving undergraduate student researchers. This work provides a practical pathway to lower the financial barriers associated with pH2 HP setups.