Epetraborole pharmacokinetics/pharmacodynamics in the hollow fiber system model of <i>Mycobacterium tuberculosis</i>
In the hollow fiber system model of tuberculosis (TB), the ratio of area under the concentration-time curve to MIC (AUC<sub>0-24</sub>/MIC) of 327.1 was identified as the epetraborole optimal exposure target for <i>Mycobacterium tuberculosis</i> kill. Monte Carlo simulation experiments showed that even the intravenous dose of 1,500 mg/twice daily would fail in the majority of patients, and the dose needed for good efficacy for TB may likely not be safe for patients.
Authors
- Shashikant Srivastava (ORCID: https://orcid.org/0000-0002-8786-8851)
- Tawanda Gumbo (ORCID: https://orcid.org/0000-0001-7592-8012)
- Sanjay Singh (ORCID: https://orcid.org/0000-0003-4601-5673)
- Megan Devine (ORCID: https://orcid.org/0000-0003-3279-1110)
Institutions
- The University of Texas at Tyler (US)
- 490 BioTech (United States) (US)
- Institute of Mathematics and Mathematical Modeling (KZ)
- Io Therapeutics (United States) (US)
- The University of Texas Health Science Center at Tyler (US)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1128/aac.00481-25
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00