BRG1 Loss Is Frequent in Lung Cancer and Transforms Lung Epithelial Cells via Transcriptional and Epigenetic Reprograming
BRG1-LOF is frequent in NSCLC; can drive the transformation of lung epithelial cells such that they acquire properties of pre-malignant cells, indicating a potential role in lung cancer initiation; and sensitizes lung tumors to epigenetic therapy.
Authors
- Christin M. Yingling
- Maria A. Picchi (ORCID: https://orcid.org/0000-0003-1067-0916)
- Loryn M Phillips (ORCID: https://orcid.org/0000-0003-3315-4009)
- Randy Willink
- Mathewos Tessema
- Steven A. Belinsky (ORCID: https://orcid.org/0000-0002-1240-2504)
- Kieu Do
Institutions
- Lovelace Respiratory Research Institute (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3390/cancers17183092
- Citations
- 1
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health