Two Physiologic Latent Classes of Acute Hypoxemic Respiratory Failure in Sepsis Are Distinguished by Lung Mechanics and Gas Exchange
We identified two physiologic latent classes of sepsis-associated AHRF. Relative to class 2, class 1 was distinguished by low compliance, impaired ventilation, and higher 30-day mortality independent of the severity of sepsis. The higher percentage of female patients and patients with obesity in class 1 suggests a potential role for body composition in class determination. Physiologic classes were not primarily determined by qualification for acute respiratory distress syndrome or previously described biomarker-based subphenotypes, suggesting a distinct physiologic "axis" of heterogeneity.
Authors
- M.G.S. Shashaty (ORCID: https://orcid.org/0000-0002-8766-3418)
- C.A.G. Ittner
- Rachel M. Bennett (ORCID: https://orcid.org/0000-0002-1533-4965)
- Gary E. Weissman (ORCID: https://orcid.org/0000-0001-9588-3819)
- Nuala J. Meyer (ORCID: https://orcid.org/0000-0003-4597-5584)
- Tiffanie K. Jones (ORCID: https://orcid.org/0000-0003-0058-8847)
- H.M. Giannini (ORCID: https://orcid.org/0000-0002-8979-3806)
- Gulus Emre
- Michaela Restivo Anderson (ORCID: https://orcid.org/0000-0001-9274-7643)
- Jason D. Christie (ORCID: https://orcid.org/0000-0003-0519-218X)
- K.C. Housel
- Rui Feng (ORCID: https://orcid.org/0000-0003-4151-7228)
- John P. Reilly (ORCID: https://orcid.org/0000-0003-3937-5320)
- Alexandra P. Turner (ORCID: https://orcid.org/0000-0003-3577-8587)
- MIKA ESPERANZA
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1097/cce.0000000000001314
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00