Cobaloxime catalyzed carbene insertion into N–H bonds: a streamlined route to α-amino esters with mechanistic insights
A cobaloxime-catalyzed N–H carbene insertion proceeds under mild conditions with low catalyst loading and broad amine scope. Mechanistic studies support a dominant cobalt–alkyl ylide pathway with minor radical involvement.
Authors
- Liming Tan (ORCID: https://orcid.org/0000-0002-5233-4489)
- Kirklin L. McWhorter (ORCID: https://orcid.org/0000-0002-1022-648X)
- Ke-Yang Wu (ORCID: https://orcid.org/0000-0002-7097-5685)
- Jesús María Hernández‐Rivas (ORCID: https://orcid.org/0000-0002-9661-9371)
- Katherine M. Davis (ORCID: https://orcid.org/0000-0002-0258-8907)
- Gang Li (ORCID: https://orcid.org/0000-0001-6680-961X)
- Madeline M Garcia
- Ayzia Ford
- Lidia M Waidmann
Institutions
- Utah State University (US)
- Emory University (US)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo01185j
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00