Population pharmacokinetic-pharmacodynamic analysis of benznidazole monotherapy and combination therapy with fosravuconazole in chronic Chagas disease (BENDITA)
This study supports prior findings that the standard 8-week benznidazole regimen is excessive. Future trials using qPCR in factorial randomized designs should evaluate both treatment duration and dosing to optimize tolerability while maintaining efficacy.
Authors
- Ivan Scandale (ORCID: https://orcid.org/0000-0003-4242-9289)
- Richard M. Hoglund (ORCID: https://orcid.org/0000-0002-5322-912X)
- Frauke Assmus (ORCID: https://orcid.org/0000-0002-1146-3452)
- Ayorinde Adehin (ORCID: https://orcid.org/0000-0003-1351-6367)
- James A Watson (ORCID: https://orcid.org/0000-0001-5524-0325)
- Cintia Cruz (ORCID: https://orcid.org/0000-0001-8393-8536)
- Nicholas John White (ORCID: https://orcid.org/0000-0002-1897-1978)
- Fabiana Barreira
- Joel Tärning (ORCID: https://orcid.org/0000-0003-4566-4030)
- M. Beatriz P.P. Oliveira (ORCID: https://orcid.org/0000-0002-6767-6596)
Institutions
- Drugs for Neglected Diseases Initiative (CH)
- Mahidol University (TH)
- University of Oxford (GB)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Infectious Diseases Data Observatory (GB)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1371/journal.pntd.0013522
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00