Using patient-reported outcomes from the PROCLAIM trial to assess the impact of universal germline genetic testing for prostate cancer patients
germline genetic testing for patients with PCa did not cause appreciable psychological harm to the tested patients. Furthermore, patients with positive results had a high uptake of clinician-recommended management strategies. Of note, there were inconsistencies in the understanding of VUS results, with some clinicians making recommendations not warranted by personal/family history; conversely, some patients pursued management strategies not recommended by their clinicians. This suggests that educational efforts are needed in the communication of germline genetic testing results and clinical recommendations to patients.
Authors
- Laurence Belkoff (ORCID: https://orcid.org/0000-0003-2789-6815)
- Edward D. Esplin (ORCID: https://orcid.org/0000-0001-9205-3756)
- Joseph Veys
- Richard Bevan-Thomas
- Christopher Pieczonka (ORCID: https://orcid.org/0000-0002-2531-7587)
- Paul Dato
- Sarah M. Nielsen (ORCID: https://orcid.org/0000-0002-5916-6393)
- Mary Kay Hardwick
- Aaron D. Berger
- David Cahn
- Brandie Heald (ORCID: https://orcid.org/0000-0003-4227-3675)
- Brianna Bucknor
- Kathryn E. Hatchell (ORCID: https://orcid.org/0000-0003-0849-7018)
- David R. Wise (ORCID: https://orcid.org/0000-0003-3419-4723)
- Kerry Aradhya
- Alexander Engelman (ORCID: https://orcid.org/0000-0003-2569-3336)
- Sean Heron
- Neal D. Shore (ORCID: https://orcid.org/0000-0001-5767-0548)
- David S. Morris (ORCID: https://orcid.org/0000-0001-9054-6899)
- Brian C. Mazzarella (ORCID: https://orcid.org/0000-0003-0349-7879)
- Mukaram Gazi
- Robert L. Nussbaum
Institutions
- University of California, San Francisco (US)
- SUNY Upstate Medical University (US)
- Genesis HealthCare (US)
- NYU Langone Health (US)
- Georgia Urology (US)
- Urology Associates (US)
- Genesis Healthcare (US)
- Syracuse VA Medical Center (US)
- AdventHealth Tampa (US)
- Nashville Oncology Associates (US)
- Invitae (United States) (US)
- Advanced Dermatology (US)
- Carolina Urologic Research Center (US)
- DGA Partners (US)
Publication Details
- Journal
- Prostate Cancer and Prostatic Diseases
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1038/s41391-025-01013-3
- Citations
- 1
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Invitae