Development and Prospective Validation of a Cell-free DNA–Based Model for the Early Detection of Pancreatic Cancer
This study develops a cfDNA-based model for early pancreatic cancer detection, demonstrating high accuracy and prospective clinical validation. By enabling presymptomatic identification and risk stratification, this noninvasive approach enhances early intervention and improves outcomes, supporting potential clinical applicability and representing a meaningful step toward improving pancreatic cancer screening and management. See related commentary by Tsui and Lo, p. 10.
Authors
- Dongqin Zhu (ORCID: https://orcid.org/0000-0002-8276-9109)
- Shuang Chang (ORCID: https://orcid.org/0009-0003-0749-0372)
- Yang Shao (ORCID: https://orcid.org/0000-0003-4585-1792)
- Chuntao Gao (ORCID: https://orcid.org/0000-0002-9954-8409)
- Xiaonan Cui (ORCID: https://orcid.org/0000-0002-4019-6680)
- Tiansuo Zhao (ORCID: https://orcid.org/0000-0003-1631-6299)
- Meng Zhang (ORCID: https://orcid.org/0000-0001-7346-6176)
- Yan Kui Sun (ORCID: https://orcid.org/0000-0001-8916-9598)
- Wei Li
- Hanfei Huang (ORCID: https://orcid.org/0000-0003-3302-823X)
- Song Gao
- Xue Wu (ORCID: https://orcid.org/0000-0002-5567-1325)
- Jun Yu (ORCID: https://orcid.org/0000-0003-3435-6550)
- Jun-Ye Zhang
- Xiuchao Wang (ORCID: https://orcid.org/0000-0002-3205-8544)
- Ruowei Yang (ORCID: https://orcid.org/0009-0007-1491-0207)
- Yanhui Zhang (ORCID: https://orcid.org/0000-0002-9314-2854)
- Shuo Li (ORCID: https://orcid.org/0000-0001-9804-8448)
- Shangheng Shi (ORCID: https://orcid.org/0009-0006-2888-476X)
- Jihui Hao (ORCID: https://orcid.org/0000-0002-1607-1730)
- Hua Bao (ORCID: https://orcid.org/0000-0001-5774-8755)
- Yunfeng Cui (ORCID: https://orcid.org/0000-0001-6415-0321)
- Yuexiang Liang (ORCID: https://orcid.org/0000-0002-5201-8187)
- Zhaoxiang Ye (ORCID: https://orcid.org/0000-0003-3157-8393)
- Hao Zhang
- Yang Liu (ORCID: https://orcid.org/0000-0001-6450-9509)
- Hongwei Wang (ORCID: https://orcid.org/0000-0001-8198-0677)
- Xiao Hu (ORCID: https://orcid.org/0000-0002-1959-9178)
- Huikai Li (ORCID: https://orcid.org/0000-0003-4864-4991)
- Jing Huang (ORCID: https://orcid.org/0000-0002-5950-4612)
- Ying Zhang
- Xingyun Chen
- W Ma (ORCID: https://orcid.org/0009-0001-0593-1299)
- Fenggang Zang (ORCID: https://orcid.org/0000-0002-1053-9099)
- Zhitao Li
- Jingjing Pei (ORCID: https://orcid.org/0009-0008-5761-3541)
- Li Peng (ORCID: https://orcid.org/0000-0001-5483-4076)
- Tianxing Zhou (ORCID: https://orcid.org/0009-0006-0150-1343)
- Jian Wang (ORCID: https://orcid.org/0000-0003-4539-7569)
Institutions
- Qingdao University (CN)
- Hebei Medical University (CN)
- Kunming Medical University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Tianjin Nankai Hospital (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Affiliated Hospital of Qingdao University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Tianjin Institute of Industrial Biotechnology (CN)
- Genesee Community College (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0323
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00