Unveiling urinary diagnostic biomarkers for diabetic kidney disease using metabolomics and machine learning approaches
This study initially identified seven DKD biomarkers with excellent diagnostic performance and further clarified their potential role in mediating DKD progression via mechanisms involving biotin metabolism, taurine and hypotaurine metabolism and steroid hormone biosynthesis. These findings provide important insights for the early precise diagnosis and mechanistic exploration of DKD.
Authors
- Hongbo Yang (ORCID: https://orcid.org/0000-0003-2741-8418)
- Yuan Sun (ORCID: https://orcid.org/0000-0003-4760-5210)
- Liming Shen (ORCID: https://orcid.org/0000-0003-0074-8556)
- Yongdong Zou (ORCID: https://orcid.org/0000-0003-2279-828X)
- Juan Yuan (ORCID: https://orcid.org/0000-0002-2745-6337)
- Haiying Li (ORCID: https://orcid.org/0000-0002-8229-764X)
- Guanwei Ma
- Yikun Zhu
- Zhiyuan Liang (ORCID: https://orcid.org/0000-0002-1528-6051)
- Wei Lu (ORCID: https://orcid.org/0000-0003-2383-7084)
- Man Zhan
- Jiancheng Li (ORCID: https://orcid.org/0000-0002-4475-8900)
- Xi Yan
Institutions
- Shenzhen University (CN)
- HKUST Shenzhen Research Institute (CN)
- The First People's Hospital of Guiyang (CN)
- Guangdong Ocean University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-21
- DOI
- https://doi.org/10.1111/dom.70138
- Citations
- 1
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 1.15