Serum Oxysterol Levels in Heart Failure With Preserved Ejection Fraction: A Prospective Case-Control Study
This is the first study to demonstrate significantly elevated serum oxysterol levels in HFpEF patients compared to healthy controls. The strong correlation with NT-proBNP suggests that oxysterols may serve as potential biomarkers for HFpEF, reflecting underlying pathophysiological mechanisms involving inflammation and myocardial remodeling. Larger, multicenter studies are warranted to confirm these findings and explore their prognostic value.
Authors
- Murat Kerkütlüoğlu (ORCID: https://orcid.org/0000-0003-1007-0574)
- Filiz Alkan Baylan (ORCID: https://orcid.org/0000-0003-3117-7768)
- Musa Dağli (ORCID: https://orcid.org/0000-0001-8927-6895)
- Hakan Güneş (ORCID: https://orcid.org/0000-0003-3853-5046)
Institutions
- Izmir University (TR)
- Necmettin Erbakan University (TR)
- Ergani Devlet Hastanesi (TR)
- Rize Devlet Hastanesi (TR)
- Kahramanmaraş Sütçü İmam University (TR)
Publication Details
- Journal
- Cureus
- Published
- 2025-09-22
- DOI
- https://doi.org/10.7759/cureus.92947
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00