Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior
The high PEGylation (150% NPs) exhibited the best antitumor effect and the lowest degree of intestinal toxicity. Our findings underscore the critical impact of PEGylation level on enhancing the performance and safety of SN38 prodrug NPs.
Authors
- Baoyuan Zhang (ORCID: https://orcid.org/0000-0002-8948-443X)
- Yanzhong Hao (ORCID: https://orcid.org/0000-0001-6710-6350)
- Yinyin Li (ORCID: https://orcid.org/0009-0006-6053-7135)
- Xiaohui Pu (ORCID: https://orcid.org/0000-0002-9359-9651)
- Xianbao Shi
- Bingjun Sun (ORCID: https://orcid.org/0000-0001-7986-5434)
- Zhihe Kuang (ORCID: https://orcid.org/0000-0003-1032-5688)
- Bowen Zhang (ORCID: https://orcid.org/0000-0002-3581-9476)
- Zhonggui He (ORCID: https://orcid.org/0000-0002-5907-3875)
- Jingxuan Zhang (ORCID: https://orcid.org/0000-0002-1358-2789)
- Lingxiao Li (ORCID: https://orcid.org/0000-0003-1628-2738)
- Ya-Fan Xiao
Institutions
- Shenyang Pharmaceutical University (CN)
- Henan University (CN)
- Ministry of Education (ME)
- The University of Tokyo (JP)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1186/s40779-025-00648-6
- Citations
- 1
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.60
Funders
- National Natural Science Foundation of China
- Liaoning Revitalization Talents Program