Essential Oils from Olea europaea and Cyperus esculentus Exhibit Promising Therapeutic Effect against Alzheimer's Disease in a Rat Model
The study suggests that serum biomarker gene expression profiles could serve as valuable indicators for differentiating between Alzheimer's disease, virgin olive oil, and dietary treatments. Both virgin olive oil and tiger nut essential oil demonstrated protective effects, enhancing cognitive function and offering therapeutic potential against AD symptoms. These effects were achieved through the reduction of inflammation, the inhibition of AChE activity, and the reduction of amyloid-beta accumulation.
Authors
- Hazem S. Elshafie (ORCID: https://orcid.org/0000-0002-6018-7319)
- Adel I. Abd Elaziz
- Sanaa S. A. Kabeil
- Gamal M. Hamad (ORCID: https://orcid.org/0000-0002-8910-4038)
- Mohamed H. El-Sheikh
- Nour Abdo (ORCID: https://orcid.org/0000-0002-4356-4653)
- Ippolito Camele (ORCID: https://orcid.org/0000-0001-8099-8234)
- Naser Ahmed Hamad Alkenani (ORCID: https://orcid.org/0000-0002-4956-2907)
- Elsayed S. Abdel Razik
- Sarah Abd-Elmohsen Abou-Alella (ORCID: https://orcid.org/0000-0003-1925-6842)
- Marwa A. Saad (ORCID: https://orcid.org/0000-0002-5739-8705)
- Sawsan Abd Ellatif (ORCID: https://orcid.org/0000-0002-7518-3759)
Institutions
- Al-Azhar University (EG)
- King Abdulaziz University (SA)
- University of Basilicata (IT)
- City of Scientific Research and Technological Applications (EG)
- Menoufia University (EG)
- Alexandria University (EG)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.2174/0113892010343085250226111914
- Citations
- 1
- Primary Topic
- Pharmacological Effects of Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 1.39